Mapping the human proteome using CRISPR-mediated fluorescence tagging, microscopy, mass spectrometry, and machine learning on SelectScience

Proteins are the product of gene expression and the molecular constructing blocks of cells. But whereas the genome sequence defines the set of all proteins that make up our cells, a scientific characterization of how the proteome is organized inside the cell stays an vital purpose of contemporary cell biology. A complete map of the human proteome’s group will function a reference to grasp gene perform in well being and illness. In this webinar, Dr. Leonetti will describe how his staff mixed CRISPR engineering, move cytometry-based cell sorting, confocal live-cell imaging, mass spectrometry, and machine learning to systematically map the subcellular localization and interactions of 1,310 human proteins. Their method supplies a data-driven description of the molecular and spatial networks that arrange the proteome.

Who ought to attend?

This webinar will present insights for cell biologists and all researchers keen on how technological advances are reworking our potential to grasp how human cells function.

Learning Objectives

Overview of CRISPR strategies for profiling gene perform
A state-of-the-art snapshot on high-throughput strategies for fluorescence microscopy and mass spectrometry
Self-supervised machine learning utilized to mobile imaging

Sony Biotechnology

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